The purpose of this research was to develop and evaluate self- micro emulsifying drug delivery system (SMEDDS) of Olmesartan medoxomil (OLM), a highly lipophilic anti- hypertensive compound. SMEDDS were prepared by combining oil, surfactant and co solvent in different ratios. 26 ratios were prepared from which only 3 ratios were passed for characterization. The prepared SMEDDS were characterized by stability studies, percentage transmittance, droplet size measurement, coalescence study and dissolution study of liquid SMEDDS in water. Two ratios were failed in stability studied.. The in-vitro release study was performed in buffer pH 7.4. The globule size was found > 50 nm. The infrared spectra showed the absence of drug-polymer interactions. The result of this study demonstrates that this drug OLM can be successfully formulated as SMEDDS formulation to increase its dissolution.
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